Into Unscientific

The visit to the Key Laboratory of Galaxy and Cosmology is undoubtedly an extremely novel experience for everyone in the project team.

Interlaced like a mountain.

This is really not a joke.

Looking at the vast starry sky, the starlight is like a curtain, and the whole person will feel a lot more open in an instant.

A round of stargazing down.

Whether it was Xu Yun or the members of the project team, everyone felt a little more relaxed, and they were all short of shouting that the advantage was mine.

With the support of this motivation and self-confidence, the project team performed the experiment on the second day.

Still failed.

no way.

Scientific research is the same as cats, it's not necessary to be realistic.

It can't be broken through with some chicken soup for the soul and chicken blood, otherwise the human beings would have counterattacked to Nanmen 2 by now.

It's just that compared to the previous day, everyone's mentality is much more stable.

It will not be affected by the failure of the project.

What can be met is.

This project is destined to be a time-consuming and labor-intensive tug-of-war, and it is difficult to see results in a short period of time.

But there is a good saying.

The east is not bright, the west is bright, and the north has the south when it is dark.

When the Diting project team was at a standstill, there was good news from Qiu Sheng:

The laboratory finished product of Yi'an bacteria toothpaste has been successfully produced!

the next morning.

4th Floor, HKUST Medical Center.

"Old Qiu."

Looking at the white sticky mass in front of him, Xu Yun couldn't help showing a strong curiosity:

"Is this the Yi'an bacteria toothpaste you made?"

Qiu Sheng on the side folded his arms around his chest, with an inscrutable look on his face:

"Of course, if it's fake, it's guaranteed to be exchanged. If it's fake, you'll pay ten."

Xu Yun glanced at him, ignoring the guy's snarky appearance:

"There is no evidence for what you say, what about the report?"

Qiu Sheng moved his chin towards Xu Yun's right, with a cold expression on his face:

"There, see for yourself."

Xu Yun gave this guy a friendly middle finger, then came to the table and read the report.

Seeing that Xu Yun started to get down to business, Qiu Sheng also let go of his hands on his chest, and explained to Xu Yun while he was reading the report:

"Old Xu, do you still remember that before we cultivated Yi'an Bacteria, the specification has reached 30,000 U per milliliter."

"The density is about 50% of that of ordinary probiotic toothpaste. The gap is obvious, but it is far lower than the concept of 'barrier'."

"After that female donkey arrived at HKUST, our supply of donkey hair increased a lot, and I was able to try various conditions with peace of mind."

"After more than a month, we finally determined the most suitable environment and temperature, and the specifications of the cultivated Yian bacteria have reached 70,000 U per milliliter."

Xu Yun nodded slightly, indicating that he understood.

mentioned earlier.

In the field of pharmaceuticals and microorganisms, the smallest potency unit with certain biological efficacy is called "unit".

It is called IU internationally.

Huaxia is called U.

There is no mutual conversion between IU and U, only the conversion between IU and weight or the conversion between U and weight.

In other words, the dosage level of U/L is a unit unique to China.

Generally speaking.

In China, most vitamins are expressed in IU.

Antibiotics are represented by U.

For example, the specification of penicillin is generally 200,000 U per milliliter, and that of erythromycin is 70,000.

The largest new species unit that Xu Yun and others found in the moss was 8000U, which is only 2000 U.

Before Xu Yun entered the wheat dungeon, the specification of Yi'an Bacteria had already broken through to 1ml and 30,000U.

Now that more than a month has passed, it is not unusual to break through to 70,000.

After all, Yi'an Bacteria itself is a strain that survives in a difficult environment, and its ability to survive and reproduce is actually very strong.

In the case of sufficient supply of donkey hair and bean dregs, it is only a matter of time to cultivate high-density strains-in simple terms, it is permutation and combination.

Then Xu Yun thought about it, and asked Qiu Sheng again:

"Old Qiu, what about the inactivation link?"

Inactivate.

This is a technique commonly used in various foods containing bacteria.

This technology is not to kill bacteria completely, but to retain the original structure and characteristics of beneficial bacteria through special means, but to make them no longer have the ability to grow and reproduce.

It looks like castration, but the difference from castration is still a bit big.

Hard to say.

It is roughly similar to the "erasing consciousness" of puppets or magic weapons in many fairy tale novels, and their own shapes are still there.

For example, the probiotics in probiotic yogurt are inactivated bacteria.

At present, in the field of microbial toothpaste, inactivation is also a key technology.

"The inactivation data is on the next page."

Qiu Sheng pointed to the report in Xu Yun's hand, motioned him to turn the page, and continued to explain:

"Actually, this is what I came to talk to you about today—the inactivation process of Yi'an Bacteria is a bit special."

Xu Yun was taken aback for a moment, and suddenly looked at Qiu Sheng with strange eyes:

"Special? Don't you want to use some materials from brother donkey again? Like donkey whip?"

".That's not the case."

The corner of Qiu Sheng's mouth twitched a few times, and he waved his hand quickly:

"It uses the E1cB mechanism."

Xu Yun was taken aback for a moment:

"E1cB mechanism? Isn't this a conventional inactivation method?"

"That's why I said it's a bit special."

Qiu Sheng took off his glasses, and scratched his auricles that were sore from the pressure of the frames:

"Old Xu, you should know that today's bacteria inactivation is actually a very mature technology, and there are no so-called patents or barriers."

"Most of the time, bacteria inactivation actually only needs to be reproduced according to certain procedures, similar to a set of formulas."

Xu Yun hummed.

As Qiu Sheng said.

The current bacterial inactivation technology is very mature, basically only a few categories:

Ultraviolet radiation inactivation, high temperature heating inactivation, repeated freeze-thaw inactivation, formaldehyde, alcohol inactivation, ordinary acid or alkali inactivation.

Like the set of formulas in basic mathematics, the inactivation process rarely encounters special situations.

"But Yi'an Bacteria is a little different."

Qiu Sheng put his glasses back on, sighed, and said:

"The activity of Yi'an Bacteria is too strong. We have used various physical or chemical methods, but the results are not satisfactory."

"Later, I thought about it. It should have something to do with the living environment of Yi'an Bacteria - the sewer is the main excretion point of the University of Science and Technology, and all kinds of sweet, salty, sour and spicy food are mixed together, so Yi'an was passively let Anbacteria acquires the property of non-deformability."

"Just like the old cousins ​​in Jiangxi, they ate spicy food every day, and finally developed resistance to spicy food."

"so."

"In the end, I can only try the quaternary amine base, using the E1cB mechanism to eliminate the hydrogen on the beta carbon of Yi'an bacteria, so as to achieve the effect of inactivation."

Xu Yun suddenly let out a sigh:

"Quaternary ammonium?"

Quaternary ammonium base.

This is a very special base.

It belongs to the same level as caustic soda in terms of alkaline strength, but technically it falls far into the category of 'alkali inactivation' mentioned above.

When the quaternary ammonium base is heated, a reaction called the Hoffmann rule will occur, which is opposite to the Zaitsev elimination rule, that is, the Zaitsev rule.

It is essentially a volume effect, and elimination from less sterically hindered sites is accomplished via E1cB.

"E1cB?"

Xu Yun stroked his chin and asked:

"One step or two?"

Qiu Sheng quickly replied:

"In two steps, the acidic proton is removed to form a stable carbanion, and then the lone pair of electrons on the carbon forms a π bond with the adjacent electrophilic carbon, forcing the leaving group to leave."

Do not know why.

After listening to Qiu Sheng's explanation.

A strange feeling suddenly appeared in Xu Yun's heart.

It was as if something was floating in front of him, but he couldn't catch it no matter what.

"."

After a while.

Xu Yun, who couldn't grasp that thought, could only sigh helplessly, and gave up the idea of ​​going further.

Strange.

Aren't you quite self-disciplined lately? Why do you feel a little lack of brain power?

Secretly muttering something that Qiu Sheng couldn't hear, Xu Yun put away the document again, and said to Qiu Sheng:

"Old Qiu, how is the effect of this toothpaste? Can it remove bad breath?"

"Toothpaste effect?"

Qiu Sheng hardly hesitated, and directly gave Xu Yun a thumbs up:

"That goes without saying, it's so good!"

I don't know if it's an illusion.

Xu Yun always felt that when Qiu Sheng said these words, there was a flash of excitement in the eyes like rain after a long drought.

However, Qiu Sheng soon noticed his abnormality, coughed lightly, and said in a formulaic manner:

"I cough, a friend of mine used this toothpaste. After using the toothpaste, the number of Neisseria and anaerobic streptococcus in the mouth dropped sharply to 1% of the original."

"In the absence of food, Yian bacteria can suppress the number of two bacteria at the line of 40% of the normal value for 12 hours."

"If the user eats food during the period, the effect of Yi'an bacteria can still last for more than four hours."

"This effect is currently on the market."

"invincible."

When Xu Yun heard this, his fingers holding the experiment report tightened.

Dimple the report paper.

In the current oral cleaning market, there is only one kind of toothpaste with relatively good effect:

That is plant lysozyme toothpaste.

Plant lysozyme can hydrolyze bacterial cell walls and dissolve a variety of oral bacteria. Plant lysozyme currently on the market is mainly extracted from figs.

From the laboratory data, it can indeed play a good effect.

However, although plant lysozyme toothpaste has good data in the laboratory, it is not satisfactory after commercialization.

Because in principle, there are four elements required for lysozyme to work:

temperature, sugar, enzyme activity and enough time.

The temperature in the human mouth is obviously suitable, and the enzyme activity will naturally not be too bad through various means.

But sugar and time is a big problem.

The little sugar on human teeth is not enough for lysozyme to work, and it only takes three minutes to brush your teeth—some people don’t have enough time, and lysozyme can’t work even if it has a great ability.

To really have a deodorizing effect, lysozyme or enzymes are not very useful, and it is still necessary to use super active bacteria such as Yian bacteria.

This is the gap between the laboratory and the actual application that has been mentioned many times before, and the gap between the two is too great.

Regrettably, there are always many manufacturers who use laboratory data to fool people or attract investment, and consumers will always be cheated in the end.

all in all.

Once Huadun Biotech's Yi'an Bacteria toothpaste is launched, it will be another blow to the deodorization market!

"Of course, Old Xu."

After introducing the effect of Yi'an Bacteria toothpaste, Qiu Sheng changed the topic again:

"At present, what we have completed is still made in the laboratory. The toothpaste material only uses basic preservatives, friction agents and foaming agents, which is far from commercialization."

"Not to mention that there are not enough donkey hairs to cultivate Yi'an bacteria. If this toothpaste is to be officially put into production, it needs to be thoroughly discussed within the company."

"But that area is not my area of ​​expertise, and I don't have any suggestions for you to refer to."

Xu Yun nodded seriously:

"I understand, thank you, Old Qiu."

well known.

As a daily necessities for cleaning the oral cavity, toothpaste is actually an abrasive at its core.

most of the time.

The content of abrasives in toothpaste may even exceed 50%.

At present, the common friction agents mainly include calcium carbonate, aluminum hydroxide, silicon dioxide, calcium hydrogen phosphate dihydrate and so on.

Among them, calcium carbonate is mainly used in low-end toothpaste, such as toothpaste in some third-rate hotels, because of its sharp crystal particles, which may wear teeth and has poor compatibility with fluoride.

Aluminum hydroxide has a certain relationship with Alzheimer's disease, so in recent years, most companies no longer use aluminum hydroxide as a toothpaste abrasive.

Therefore, the common abrasives used in the production of toothpaste are generally the latter three.

The three types of friction agents are different and the prices are also different.

What kind of material needs to be selected in the commodity stage needs further analysis.

In addition, there are thickeners, flavors, taste improvers, appearance improvers, acid-base buffers, antioxidants, etc., which need to be studied separately.

After all, no matter how effective a toothpaste is, it is uncomfortable to use without any taste.

Most of the so-called whitening and bactericidal effects of many toothpastes on the market are based on the psychological hints brought by the coolness of mint.

Other than that.

The company still needs to obtain some relevant procedures before it can produce toothpaste-but this matter is not difficult.

When Qiu Sheng started to study the expansion of Yi'an Bacteria, Xu Yun and Gu Qunqing had already settled down, and the relevant procedures had already begun.

Domestic toothpaste only needs product inspection reports and product safety assessment data, and then obtains the serial number of the filed product in the administrative region and the prepared word of the national tooth network.

At present, the basic departments of Huadun Biotechnology have been established one after another, and Gu Qunqing has already arranged manpower to submit relevant applications.

As long as the commercialization process is completed, the toothpaste can be on the shelves within a few days.

And the potential market for this toothpaste.

Undoubtedly, it is also an astonishingly large value.

After more than half an hour.

Xu Yun left the laboratory.

As a result, not long after he walked out of the medical center, his cell phone rang.

Xu Yun took it out and saw that the note was .

【Mom】.

Xu Yun's contact with his family is quite frequent, and he will make a video call or something in a day or two, so he presses the dial button as usual.

But the next second.

Xu Yun was so excited that he almost didn't throw the phone out:

"Son, Mom introduced you to a girl who is in Luzhou. When do you think you can go on a blind date?"