Start with the cell editor

Next, Lu Li's little life was very comfortable.

The brothers and sisters in the laboratory are very enthusiastic, and if he has any questions, the brothers and sisters will take the initiative to help, and he also gets along very well with these brothers and sisters.

When he wasn't in the laboratory, Lu Li was usually accompanied by Senior Sister Qin Wei and played near the school, but he hadn't confirmed the relationship with Qin Wei yet, and it was better to have a gradual relationship.

At the same time, he also took the time to register a patent related to single-base gene editing technology, which is not a black technology that is ahead of the times, and must first register a patent in order to better protect his interests.

On this day, eight o'clock in the evening.

Inside the laboratory.

"Senior Brother Lu, see you tomorrow. "

A senior brother took off his scientific research uniform and said goodbye to Lu Li.

"See you tomorrow. "

Lu Li smiled and continued to use the micromanipulation instrument to observe the cells in the petri dish.

He is experimenting with single-base gene editing technology.

The experimental material was the blood of a cancer patient.

He extracts immune cells from blood samples and uses single-base gene editing to inactivate the gene that encodes the PD-1 protein in the immune cells.

PD-1, also known as the programmed death receptor on the surface of immune cells, blocks the killing of cancer cells by immune cells once it binds to the ligand PD-L1 on cancer cells.

If this experiment is successful, only the gene-edited cells need to be injected into the patient's body, which can enhance the killing power of the patient's immune cells against cancer cells, so that cancer patients can benefit.

"It's so cumbersome to do these experiments in the lab. "

Lu Li sighed softly.

Through the cell editor, he can perfectly control the cells in his body, and perform atomic-level manipulation of any matter in the cell, as for modifying genes, it is not too simple.

However, it is a lot of trouble to use these instruments in the laboratory to do experiments, and the existing instruments cannot accurately manipulate genes, and special methods must be used, and the single-base gene editing technology he built is one of them.

"Hey, it can't be said that the current instrument is too backward, the main reason is that my plug-in is too strong. "

Lu Li smiled again and continued the experiment.

After a long night of research, it was quickly dawning.

Professor Xu walked in wearing a scientific research suit, and when he saw Lu Li, he said with some concern: "You didn't rest last night and have been doing experiments?"

"The experiment reached a critical stage where I needed to keep an eye on it, and luckily, it was a success. "

Lu Li showed a bright smile, picked up an experimental data report, and handed it to Professor Xu, "I used single-base gene editing technology to successfully inactivate the gene responsible for encoding the PD-1 protein in immune cells, and the off-target rate is very low, only 1.3%. "

The so-called off-target refers to the editing of other genes.

For example, if you want to edit gene A, you end up editing gene B.

This is a serious security risk.

At present, the mainstream CRISPR-Cas9 gene editing technology has a high off-target effect, which is an important reason why CRISPR-Cas9 gene editing technology cannot be commercialized.

"I'll take a look!".

Professor Xu excitedly took the document handed over by Lu Li and read it, the more he looked at it, the happier he became, and a bright smile gradually bloomed on his face.

"Sure enough, as I judged, the single-base gene editing technology you invented is at least ten times more advanced than the CRISPR-Cas9 gene editing technology, with this technology, the field of gene editing technology is about to enter a new era, however, these data are not enough, you do a few more sets of experiments, collect some data, and then you can write a paper, after writing, I will help you look at it, and then vote it to "Cell". "

Professor Xu said excitedly.

Lu Li nodded, he didn't care about resting, he hurriedly ate something, and continued the experiment, and he was busy until the afternoon, completed four more sets of experiments, and recorded the experimental data.

"Perfect!".

Professor Xu has been observing and guiding from the side, and when he saw these data, he suddenly slapped his thigh, and he was so excited that he felt that accepting Lu Li as a student might be the proudest thing in his life. This student is simply genius!

"I'm rubbing, awesome!".

"Senior Brother Lu, from now on, you will be my idol!".

"Judging from these experimental data, single-base gene editing technology is more advanced than CRISPR-Cas9 gene editing technology in all aspects, and can completely replace CRISPR-Cas9 gene editing technology!

"Senior Brother Lu will be my bragging capital in the future. "

The others had also been observing from the side, and they couldn't help cheering at this time, looking at Lu Li's eyes, full of envy and respect, as if they saw a great scientist rising.

As for jealousy, it doesn't exist, jealousy only arises when the gap is not big, and when the gap is large enough to a certain extent, there is only admiration and worship!