The Rise of the European Emperor

While Marin was busy planning the metropolitan area, Gollard, who was in Panama, sent a boat back to Europe to report to Marin that several young men had died of malaria due to mosquito bites.

Although, Marin gave Gollard a lot of mosquito repellent toilet water. However, not everyone routinely applies toilet water to themselves every day. Some young men, relying on their youth, are not stable enough. When it was time to apply toilet water, they simply did not apply it for fear of trouble. So, in the end, something happened, and a few strong guys got malaria after being bitten by mosquitoes, and then died like this.

This incident caused panic among immigrants in Panama. Some people even cried with fear and wanted to go back to Europe. Gollard had no other way than to press. Right now, because of the panic in the hearts of those white immigrants, they don't even have the mood to drive those black people to cut down trees, which has led to a pause on the issue of road opening in Panama. So, Gollard sent people back to the country to ask Marin for help. After all, he heard that there were two genius doctors, Mo Zhigen and Bartle, around Marin, and he hoped they could give a solution.

However, where can Morigen and Battell provide any solutions? Before cinchona was discovered, malaria was incurable. In China, it is believed that malaria is caused by tropical miasma entering the body. Therefore, the ancient Chinese people always regarded Lingnan as a dangerous place. Many officials who committed crimes were exiled to Lingnan as a serious punishment.

In fact, if ancient Huaxia could find an effective treatment for malaria, Lingnan would have been developed on a large scale long ago. Even Vietnam will become the coveted target of the Central Plains dynasty.

The reason why the Central Plains Dynasty abandoned Vietnam was because Vietnam was tropical and prone to malaria. It is easy to die from malaria, and the people of the Central Plains are naturally not willing to go there. In addition, the chiefs of Vietnam like to pay tribute and hold their thighs, and they are good at patting horses, so the Central Plains Dynasty is even more reluctant to conquer Vietnam. Of course, when it comes to flattery, the Vietnamese can't keep up with North Korea. The ancestors of Bangzi would clasp their horses and hug their thighs, and Zhu Yuanzhang was so happy that he directly listed North Korea as a country not to be conquered. But in fact, North Korea's climate is much better than Vietnam's, and there is no miasma, which is actually very suitable for living. But they flattered them well, and they went to the palace of the Ming Dynasty to send Korean beautiful women with all their might, and the emperor fell under the pomegranate skirt. There are even rumors that the biological mother of Ming Chengzu Zhu Di may be a North Korean concubine. Although this statement is not reliable, it is certain that there are North Korean concubines in the palace of the Ming Dynasty. According to records, Emperor Yongle Zhu Di and his grandson Xuande Emperor Zhu Zhanji each took 8 North Korean concubines... They had the nerve to conquer others after they were caught in their beauties?

Oops, off topic, but anyway, if ancient China had obtained the magic medicine for malaria, it would have conquered Vietnam long ago, and maybe even conquered places such as Laos, Cambodia, and Thailand. But because of fear of "miasma", it did not continue to expand south.

However, as a traveler of later generations, Marin knew that ancient China was only one step away from treating malaria...

Before Marin crossed over, he knew that the later Chinese god Tu yoyo discovered artemisinin, a magic medicine for malaria that was more effective than cinchona cream.

Because Tu Yoyo won the Nobel Prize in Medicine, Marin's previous life was widely reported by the media, which made Marin, a liberal arts student, also have a strong interest in artemisinin, and consulted relevant materials.

The reason why it is said that ancient China is only one step away from treating malaria is because of the particularity of artemisinin.

Artemisinin, as the name suggests, is naturally extracted from Artemisia annua. In ancient China, Artemisia annua was listed as a herbal medicine for a long time, and it should be said that it can cure malaria long ago.

But this is not the case. This is because the most important thing is to boil the medicine for a long time, which is called boiling medicine. The problem lies in this boiled medicine...

Why? Because artemisinin is a substance that cannot be heated, it is easily converted into other substances when heated, and loses the function of treating malaria. Traditional Chinese medicine needs to be boiled in a pot for a long time. Once the artemisinin is boiled, the natural efficacy of the medicine disappears or is greatly reduced, making it impossible to treat malaria. Therefore, ancient China never knew that Artemisia annua could treat malaria.

Of course, not everyone knows this. In the Ming Dynasty, there were some powerful doctors who knew that Artemisia annua could be used to treat malaria. However, this method has not spread widely. Traditional Chinese medicine naturally advocates boiling medicine, so people cannot overcome the stubborn malaria.

By searching for relevant information, later generations of Marin knew that the temperature for extracting artemisinin should not exceed 70 degrees, so as to avoid the loss of efficacy conversion.

And, very importantly - artemisinin is insoluble in water. This makes it extremely difficult to extract.

If artemisinin was soluble in water, it would be simple. Chop the wormwood directly and soak it in water. Artemisinin can be obtained directly by air-drying without heating.

But the problem is, artemisinin is insoluble in water...

When Tu Yoyo was researching and developing it, he heard that the ancients used the method of ingesting Artemisia annua to treat malaria, so he tried every means to extract this substance. However, it has been unsuccessful.

Until one day, she suddenly felt, is this substance insoluble in water? So, she used ether to soak the artemisinin, and sure enough, artemisinin was extracted. Later, a production method of extracting artemisinin by gasoline immersion was also developed...

But Marin knew that artemisinin was soluble not only in ether and gasoline, but also in alcohol…

Because both alcohol and ether are similar substances with similar properties. Of course, according to the summary of later generations, the use of alcohol to extract artemisinin may not be as effective as ether and gasoline, but it is still able to extract artemisinin. Because artemisinin is soluble in alcohol.

Coincidentally, Marin now owns a lot of grain-brewed wine, and also extracts and manufactures a lot of medical alcohol. Moreover, as a liberal arts student, Marin did not know how to produce ether. Without oil, he couldn't get gasoline. Therefore, using alcohol to extract artemisinin has become Marin's only choice.

It just so happened that there was a very small amount of Artemisia annua in the herbal seeds that Mo Zhigen and Battelle brought before. Although the quality of Artemisia annua in the northern grasslands may not be good, far less than the artemisinin content of Youyang Artemisia annua, it can also be used to extract artemisinin.

Moreover, now Marin's subordinates have planted hundreds of acres of artemisia grass in a remote manor belonging to Marin near Aurich.

Gollard didn't write, and Marin almost forgot about the wormwood. But now, Marin thinks about it—it seems that he can use those artemisinin to extract artemisinin...

So, Marin sent someone to the manor and brought in a large reserve of Artemisia annua...

At the same time, Marin went to the brewery, got a lot of medical alcohol, and started the work of extracting artemisinin...

Marin first sent someone to chop up the wormwood, then soaked it in medical alcohol and covered it (alcohol is volatile).

After a long time, Marin asked people to open the lid and filter out the dregs of artemisinin with gauze, and obtained an alcohol solution in which artemisinin was dissolved.

Then, in order not to waste alcohol, Marin asked people to find a large pot for steaming wine, and started to heat the solution intermittently with a small fire, trying to keep the temperature of the solution below 70 degrees.

Then, the alcohol passes through the cooling pipe, drips little by little, and is recovered into a specific container, ready to be reused...

When the alcohol was running out, Marin was putting the foundation directly in the air to dry. Then, I got artemisinin with a very mixed color...

This is because Marin did not use activated carbon to absorb some impurities such as pigments in the solution, which made the extracted artemisinin look ugly.

But Marin doesn't care, as long as it works, what about his appearance?

It's just that the acquisition rate of this artemisinin is really touching - it is less than one thousandth...

Although there are problems with the extraction process, resulting in incomplete extraction, you must know that the artemisinin content of Youyang Artemisia annua exceeds 8/1,000. Therefore, the artemisinin content of Youyang Artemisia annua is several times that of the ordinary Artemisia annua brought by Mo Rigen and Bartel... This gave Marin a strong desire to go to Daming to find the seeds of Youyang Artemisia annua...

But anyway, Marin got a lot of artemisinin. Nearly 10 pounds of artemisinin was extracted from the 10,000 pounds of artemisinin hay shipped.

You must know that there are tens of thousands of pounds of artemisinin in the manor. If they are extracted, dozens of pounds of artemisinin can be extracted. In the treatment of a malaria patient, the dosage of artemisinin is only 6 to 12 grams. Even according to the maximum calculation of 12 grams, 10 pounds of artemisinin can cure 378 patients. After that, dozens of pounds of artemisinin are extracted, which is enough to cure more than 1,000 malaria patients...

After getting these artemisinins, Marin was overjoyed and ordered people to make a lot of oil paper bags to pack these artemisinins. Moreover, Marin asked people to make small oil-paper bags weighing 12 grams for the convenience of his subordinates. If an able-bodied man has malaria, and it is severe, use the whole pack of 12 grams of artemisinin for him to take. And if it is the elderly and children with weak resistance, pouring out a part of the bag is enough to cure. In this way, it is also greatly convenient for doctors to use.

Marin put the 10 pounds of artemisinin in his hand into 378 small oil paper bags, and sealed them to avoid moisture damage. Then, he planned to send a ship to Gollard. Of course, Tara from Cuba Island will also send some.

As for the other artemisinin in the manor, the extracted artemisinin, Marin plans to distribute to the people of the ocean-going fleet, so as to deal with emergencies along the way. Moreover, artemisinin can not only treat malaria, but also treat malignant diseases such as kala-azar and lupus erythematosus. It is a magic medicine. Of course, because it is rare and precious, it is best used to deal with serious diseases such as lethal malaria. It's a waste to use it to treat minor illnesses...